Everything about Therapeutic Window totally explained
Therapeutic window (or pharmaceutical window) is an
index for estimation of
drug dosage which can treat disease effectively while staying within the safety range. In other words, it's the dosage of a
medication between the amount that gives an effect (
effective dose) and the amount that gives more
adverse effects than desired effects. For instance, medication with a small pharmaceutical window such as
Tegretol must be administered with care and control, for example by frequently measuring blood concentration of the drug, since it easily gives adverse effects such as
agranulocytosis.
More specifically, it's the range between the
ED50 and the starting point of
LD50 curve. It is believed that this index can help to avoid most of the potential
side effects.
This index is believed to be more reliable than that of therapeutic index since this index considers the biological variation among individuals to a larger extent.
See also
Therapeutic index
Reference
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